Olmesartan medoxomil is an angiotensin type II receptor blocker, antihypertensive agent, administered orally. It is highly lipophilic log P 5. The poor dissolution rate of water-insoluble drugs is still a major problem confronting the pharmaceutical industry. The objective of the present investigation was to develop liquisolid compacts for olmesartan medoxomil to improve the dissolution rate. Liquisolid compacts were prepared using Acrysol El as a solvent, Avicel PH , Fujicalin and Neusilin as carrier materials, and Aerosil as coating material in different ratios. The interaction between drug and excipients was characterized by DSC and FT-IR studies, which showed that there is no interaction between drug and excipients.
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The challenge faced by the majority of the pharmaceutical products is the poor solubility of the drug candidates which leads to low bioavailability. Liquisolid compact is one of the emerging techniques that enhances the dissolution of poorly water soluble drugs.
Liquisolid system mentions to the formulation made by the transforming the liquid drug, either in the form of suspension or solution in non volatile solvents into a dry, non-sticky, free-flowing and compactable powder mixtures.
This is achieved by mixing the suspension or solution of the drug with appropriate carriers and coating agents. The technology has the ability to increase aqueous solubility, rate of dissolution and absorption of poorly soluble drug by keeping it in molecularly dispersed form leading to its improved bioavailability when compared to conventional tablets.
Liquisolid technology is the impending approach for enhancing the solubility of poorly water-soluble drug by adopting simple manufacturing process and low production cost. Skip to main content Skip to main navigation menu Skip to site footer.
Abstract The challenge faced by the majority of the pharmaceutical products is the poor solubility of the drug candidates which leads to low bioavailability.
Downloads Download data is not yet available. References 1. Liquisolid compact: a new technique for enhancement of drug dissolution. Int J Pharm Res Dev ; Int Res J Pharm ; Liquisolid technology: a technique for formulation with enhanced bioavailability. World J Pharm Pharm Sci ; Improved oral delivery of clonazepam through Liquisolid powder compact formulation: in vitro and ex vivo characterization. Powder Technol ; Peddi MG.
Novel drug delivery system: liquid-solid compact. Swati M. Solubility enhancement of a drug by liquisolid technique. Design and technology of liquisolid compacts.
J Appl Pharm Sci ; Effect of powder substrate on the dissolution properties of methchrothiazide liquisolid compacts. Drug Dev Ind Pharm ; Microwave-induced enhancement of the dissolution rate of poorly water-soluble tibolone from poly ethylene glycol solid dispersions. J Appl Polymer Sci ; Schiermeier S, Schmidt PC. Fast dispersible ibuprofen tablet. Eur J Pharm Sci ; Tiong N, Elkordy AA.
Effects of liquisolid formulations on the dissolution of naproxen. Eur J Pharm Biopharm ; Liquisolid Compacts. A novel approach to enhance bioavailability of poorly soluble drugs. Int J Pharm Bio Sci ; Spireas S, Sadu S. Enhancement of prednisolone dissolution properties using liquisolid compacts. Int J Pharm ; Suitability of various excipients as carrier and coating materials for liquisolid compacts.
Dissolution enhancement technique of poorly soluble drug by Liquisolid compact. Drug release from liquisolid systems: speed it up, slow it down.
Expert Opinion Drug Delivery ; Liquisolid technique: a novel approach for dosage form design. Int J Appl Pharm ; Competence of raloxifene hydrochloride loaded liquisolid compacts for improved dissolution and intestinal permeation. Liquisolid compacts: a novel approach to enhance bioavailability of poorly soluble drugs.
Liquisolid technology applied to pellets: evaluation of the feasibility and dissolution performance using felodipine as a model drug. Chem Eng Res ; Khaled KA. Formulation and evaluation of hydrochlorothiazide liquisolid tablets. Saudi Pharm J ; Improvement of dissolution properties of carbamazepine through the application of the liquisolid tablet technique.
Eur J Pharm Biopharm ; Microcrystals for dissolution rate enhancement of poorly water-soluble drugs. The influence of Thermal treatment on the release behaviour of diclofenac sodium from an acrylic material.
Pharm Dev Technol ; Gubbi S, R Jarag. Liquisolid technique for enhancement of dissolution properties of Bromhexine Hydrochloride. Res J Pharm Tech ; Liquisolid technique for sustaining the drug release from compacts. J Pharm Res ; Nokhodchi A. Liquisolid compacts: the effect of cosolvent and HPMC on theophylline release. Colloids Surf B ; Evaluation of in vitro dissolution profile comparison methods of sustained release tramadol hydrochloride liquisolid compact formulations with marketed sustained-release tablets.
DJNB ; Liquisolid technique: a review. Int J Pharm Sci Res ; Liquisolid systems: a review. Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug carbamazepine. Formulation and characterization of liquisolid compacts of valsartan. Khan A, Agrawal S. Formulation and evaluation of lumefantrine capsule prepared by using the liquisolid technique. Int J Curr Pharm Res Formulation and evaluation of Simvastatin liquisolid tablets. Powdered solution technology: principles and mechanism.
In vitro release evaluation of Hydrocortisone liquisolid tablets. J Pharma Sci ; Formulation and characterization of liquisolid tablets of Valsartan for improvement of dissolution rate. Asian J Pharm Clin Res ; Dissolution enhancement of drugs. Part I: technologies and effect of carriers. Int J Health Res ; Liquisolid compacts: a promising approach for solubility enhancement.
J Drug Delivery Ther ; Stegemann S, Leveiller F. When poor solubility becomes an issue: From early stage to proof of concept. Gavhane KS, Sayyed F. Liquisolid compact a review. Int J Pharm Bio Res ; Patel N. Liquisolid dosage system: a novel approach for dosage formulation. J Pharm Sci Biosci Res ; Parthasarathi S, Anandharamakrishnan C.
Enhancement of oral bioavailability of vitamin E by spray-freeze drying of whey protein microcapsules. Food Bioproducts Processing ; Int J Appl Pharm A review on pharmaceutical application of liquisolid echnique.
Preparation and Characterization of Liquisolid Compacts for Improved Dissolution of Telmisartan
Background Meloxicam MXM is a poorly soluble drug and its low aqueous solubility leads to poor dissolution and bioavailability. Aim The aim of this study was to investigate the potential of a liquisolid system to improve the dissolution rate and the bioavailability of MXM. Materials and methods The liquisolid compacts were prepared using Avicel PH as a carrier material, Aerosil as a coating material, Polyethylene glycol as a liquid vehicle, and sodium starch glycolate as a superdisintegrating agent. The 15 liquisolid compact formulations were prepared by varying drug concentrations in the liquid vehicle.
LIQUISOLID COMPACTS: AN INNOVATIVE APPROACH FOR DISSOLUTION ENHANCEMENT
Patel, R. Vadodara , India. This investigation was aimed to improve the dissolution rate of the poorly soluble drug lovastatin, by formulating it as a liquisolid compact. Different liquisolid compacts were prepared using mathematical formulae to calculate the required quantities of powder and liquid ingredients to produce acceptably flowable and compressible admixture. Avicel PH , Cab-O-Sil, sodium starch glycolate and PEG were employed as carrier, coating material, disintegrant and non-volatile liquid vehicle, respectively. The various drug to liquid and carrier to coating ratio were used to prepare liquisolid compacts. The formulated liquisolid tablets were evaluated for weight variation, hardness, drug content, friability and disintegration time.