Olmesartan medoxomil is an angiotensin type II receptor blocker, antihypertensive agent, administered orally. It is highly lipophilic log P 5. The poor dissolution rate of water-insoluble drugs is still a major problem confronting the pharmaceutical industry. The objective of the present investigation was to develop liquisolid compacts for olmesartan medoxomil to improve the dissolution rate. Liquisolid compacts were prepared using Acrysol El as a solvent, Avicel PH , Fujicalin and Neusilin as carrier materials, and Aerosil as coating material in different ratios. The interaction between drug and excipients was characterized by DSC and FT-IR studies, which showed that there is no interaction between drug and excipients.

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The challenge faced by the majority of the pharmaceutical products is the poor solubility of the drug candidates which leads to low bioavailability. Liquisolid compact is one of the emerging techniques that enhances the dissolution of poorly water soluble drugs.

Liquisolid system mentions to the formulation made by the transforming the liquid drug, either in the form of suspension or solution in non volatile solvents into a dry, non-sticky, free-flowing and compactable powder mixtures.

This is achieved by mixing the suspension or solution of the drug with appropriate carriers and coating agents. The technology has the ability to increase aqueous solubility, rate of dissolution and absorption of poorly soluble drug by keeping it in molecularly dispersed form leading to its improved bioavailability when compared to conventional tablets.

Liquisolid technology is the impending approach for enhancing the solubility of poorly water-soluble drug by adopting simple manufacturing process and low production cost. Skip to main content Skip to main navigation menu Skip to site footer.

Abstract The challenge faced by the majority of the pharmaceutical products is the poor solubility of the drug candidates which leads to low bioavailability.

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Preparation and Characterization of Liquisolid Compacts for Improved Dissolution of Telmisartan

Background Meloxicam MXM is a poorly soluble drug and its low aqueous solubility leads to poor dissolution and bioavailability. Aim The aim of this study was to investigate the potential of a liquisolid system to improve the dissolution rate and the bioavailability of MXM. Materials and methods The liquisolid compacts were prepared using Avicel PH as a carrier material, Aerosil as a coating material, Polyethylene glycol as a liquid vehicle, and sodium starch glycolate as a superdisintegrating agent. The 15 liquisolid compact formulations were prepared by varying drug concentrations in the liquid vehicle.



Patel, R. Vadodara , India. This investigation was aimed to improve the dissolution rate of the poorly soluble drug lovastatin, by formulating it as a liquisolid compact. Different liquisolid compacts were prepared using mathematical formulae to calculate the required quantities of powder and liquid ingredients to produce acceptably flowable and compressible admixture. Avicel PH , Cab-O-Sil, sodium starch glycolate and PEG were employed as carrier, coating material, disintegrant and non-volatile liquid vehicle, respectively. The various drug to liquid and carrier to coating ratio were used to prepare liquisolid compacts. The formulated liquisolid tablets were evaluated for weight variation, hardness, drug content, friability and disintegration time.

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