EPATITE AUTOIMMUNE PDF

Autoimmune hepatitis is characterized by autoantibodies, hypergammaglobulinemia, and interface hepatitis on histological examination. The features lack diagnostic specificity, and other diseases that may resemble autoimmune hepatitis must be excluded. The clinical presentation may be acute, acute severe fulminant , or asymptomatic; conventional autoantibodies may be absent; centrilobular necrosis and bile duct changes may be present; and the disease may occur after liver transplantation or with features that suggest overlapping disorders. The diagnostic criteria have been codified, and diagnostic scoring systems can support clinical judgment.

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Giuseppe Maggiore, Marco Sciveres. Autoimmune hepatitis AIH is an uncommon disease occurring mainly in women and characterised by the morphological changes of interface hepatitis on liver biopsy, hypergammaglobulinemia, elevated serum aminotransferases, and circulating autoantibodies.

AIH is thought to have a basis in aberrant outoreactivity to hepatocyte antigens in genetically predisposed individuals. AIH is notably heterogeneous with respect to its clinical expression and laboratory features and patients may present without obvious clinical evidence of liver disease or with an acute hepatitis. Sustained response to therapy may result in substantial regression of fibrosis even in advanced cases.

Rapid withdrawal of immunosuppression is associated with high risk of disease relapse in many patients. Alternative strategies in patients who have failed to achieve remission on "standard therapy" include the use of cyclosporine.

Liver transplantation is the treatment of choice in managing patients with decompensated disease unresponsive to "rescue" medical treatment. Epatite autoimmune : Cinquant'anni e non li dimostra! N2 - Autoimmune hepatitis AIH is an uncommon disease occurring mainly in women and characterised by the morphological changes of interface hepatitis on liver biopsy, hypergammaglobulinemia, elevated serum aminotransferases, and circulating autoantibodies.

AB - Autoimmune hepatitis AIH is an uncommon disease occurring mainly in women and characterised by the morphological changes of interface hepatitis on liver biopsy, hypergammaglobulinemia, elevated serum aminotransferases, and circulating autoantibodies. Epatite autoimmune: Cinquant'anni e non li dimostra! Translated title of the contribution : Autoimmune hepatitis: Fifty years after. Abstract Autoimmune hepatitis AIH is an uncommon disease occurring mainly in women and characterised by the morphological changes of interface hepatitis on liver biopsy, hypergammaglobulinemia, elevated serum aminotransferases, and circulating autoantibodies.

Autoimmune Hepatitis. Remission Induction. Liver Transplantation. Liver Diseases. Adrenal Cortex Hormones. Medico e Bambino , 21 5 , In: Medico e Bambino , Vol. Maggiore G , Sciveres M. Medico e Bambino.

Maggiore, Giuseppe ; Sciveres, Marco. In: Medico e Bambino. Access to Document Link to publication in Scopus. Link to citation list in Scopus.

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Diagnosis and Management of Autoimmune Hepatitis: Current Status and Future Directions

Other signs and symptoms that may develop as the disease progresses include: [1] [2] [3] [4]. This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly.

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Autoimmune hepatitis

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Autoimmune Hepatitis Scoring System

Autoimmune hepatitis , formerly called lupoid hepatitis , is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells , causing the liver to be inflamed. Common initial symptoms include fatigue or muscle aches or signs of acute liver inflammation including fever, jaundice , and right upper quadrant abdominal pain. Individuals with autoimmune hepatitis often have no initial symptoms and the disease is detected by abnormal liver function tests. Anomalous presentation of MHC class II receptors on the surface of liver cells, [2] possibly due to genetic predisposition or acute liver infection , causes a cell-mediated immune response against the body's own liver, resulting in autoimmune hepatitis. This abnormal immune response results in inflammation of the liver, which can lead to further symptoms and complications such as fatigue and cirrhosis.

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