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Investigating Shigella sonnei Infections. Shigella Sonnei and Shiga Toxin. Katherine Lamba, an infectious disease epidemiologist with the California Department of Public Health, discusses Shiga Toxin producing Shigella sonnei. Directory of Open Access Journals Sweden.

Shigella sonnei bacteremia in an elderly diabetic patient. A case of Shigella sonnei bacteremia in a year-old patient suffering from diabetes mellitus is discussed. The isolated strain had plasmid-mediated serum resistance and excreted aerobactin.

The presence of diabetes mellitus as an underlying disease and the production by the Shigella sonnei isolate of factors related to bacterial invasion may have contributed to the bacteremic episode. Vulvovaginitis caused by Shigella species Shigella spp. This paper describes two cases of prepubertal vulvovaginitis, presenting with a bloody and purulent vaginal discharge, separately caused by ampicillin-resistant Shigella flexneri and trimethoprim-sulfomethoxazoleresistant Shigella sonnei.

Our conclusions are that Shigella spp. An O antigen capsule modulates bacterial pathogenesis in Shigella sonnei. Shigella is the leading cause for dysentery worldwide. Together with several virulence factors employed for invasion, the presence and length of the O antigen OAg of the lipopolysaccharide LPS plays a key role in pathogenesis.

Here we reveal that S. We found that a galU mutant of S. High molecular weight material not linked to the LPS was purified from S. Deletion of genes homologous to the group 4 capsule synthesis cluster, previously described in Escherichia coli, abolished the generation of the high molecular weight OAg material.

This OAg capsule strongly affects the virulence of S. Uncapsulated knockout bacteria were highly invasive in vitro and strongly inflammatory in the rabbit intestine. But, the lack of capsule reduced the ability of S.

In contrast, overexpression of the capsule decreased invasiveness in vitro and inflammation in vivo compared to the wild type. In conclusion, the data indicate that in S.

Full Text Available Shigella is the leading cause for dysentery worldwide. This paper describes two cases of prepubertal vulvovaginitis, presenting with a bloody and purulent vaginal discharge, separately caused by ampicillin-resistant Shigella flexneri and trimethoprim-sulfomethoxazole-resistant Shigella sonnei.

Symptomatic Shigella sonnei urinary tract infection in pregnancy. This report describes a case of urinary tract infection UTI due to Shigella sonnei during pregnancy. A year-old pregnant woman was admitted complaining of left-flank tenderness, dysuria, and fever. Urinalysis revealed 30 to 50 leukocytes per high power field while from the quantitative urine culture Shigella sonnei was recovered after 24 h incubation at 37 degrees C. After a two-week course with mg cefuroxime every 8 h, the patient experienced gradual resolution of all symptoms and urinary cultures were negative two weeks and one month, respectively, after completing the therapy.

The gestational course was uneventful and the patient delivered a healthy baby girl at term. Shigella sonnei can be responsible for UTI during pregnancy even when no predisposing factors or an apparent source of infection can be identified. Fractionation and purification of DNA methylases of Shigella sonnei. A comparative study was made of the possibilities of various types of column chromatography and isoelectrofocusing for the analysis of the set of DNA methylases of the strains Shigella sonnei On the basic of cation-exchange chromatography, a simple, rapid, and convenient method has been developed for the production of a highly active summary preparations of DNA methylases.

It has been shown that affinity chromatography on heparin-Sepharose provides for the separation of methylases according to the characteristic of specificity for the nitrogen base. Increased ability of the DNA methylases of Shigella sonnei 47 for nonspecific aggregation during the process of fractionation was demonstrated, which makes the use of column chromatography unsuitable for the isolation and purification of individual methylating enzymes of the investigated strain.

The advantages of the IEF method, as well as its potentialities from the standpoint of studying various molecular forms of site-specific enzymes, are discussed.

International foodborne outbreak of Shigella sonnei infection in airline passengers. During August , an outbreak of Shigella sonnei infection affected air travellers who departed from Hawaii.

Forty-seven passengers with culture-confirmed shigellosis and probable cases who travelled on 12 flights dispersed to Japan, Australia, 22 US states, and American Samoa. All flights were served by one caterer. Pulsed-field gel electrophoresis of all 29 S. Food histories and menu reviews identified raw carrot served onboard as the likely vehicle of infection. A total of meals were served on flights with confirmed cases; using attack rates observed on surveyed flights, we estimated that passengers were infected.

This outbreak illustrates the risk of rapid, global spread of illness from a point-source at a major airline hub. Full Text Available Ciprofloxacin resistant Shigella sonnei across the globe have been increasing alarmingly. In order to understand the emergence of S. Of the Shigella sp. Isolated from to , 34 S. None hadqnrA, qnrS and qepA. Two 0. All isolates harboured the ipaH gene followed by ial None had stx1 element.

A documented increase in S. Outer membrane proteins analysis of Shigella sonnei and evaluation of their antigenicity in Shigella infected individuals. Full Text Available Bacillary dysentery caused by infection with Shigella spp. It is a highly multi drug resistant organism and rarely identified from the patient at the early stage of infection. The antigenicity of outer membrane protein of this pathogen expressed during human infection has not been identified to date.

We have studied the antigenic outer membrane proteins expressed by S. Three antigenic OMPs sized The antigenic proteome data generated in this study are a first for OMPs of S. Furthermore, numerous prime candidate proteins were identified which will aid the development of new diagnostic tools for the detection of S. Shigella sonnei and hemolytic uremic syndrome: A case report and literature review.

Full Text Available Hemolytic uremic syndrome HUS is a well-described process that is known to cause severe renal dysfunction, thrombocytopenia, and anemia. HUS is typically associated with toxins shiga-like and shigella toxin found in strains of E.

We present a case of a 27 year-old man with jaundice, thrombocytopenia, and renal dysfunction who was found to have HUS in the setting of Shigella sonnei infection. Outside of developing countries, cases of HUS related to S. Shigella sonnei and Salmonella Typhi cause significant morbidity and mortality. We exploited the safety record of the oral, attenuated S. Typhi vaccine Ty21a by using it as a vector to develop a bivalent oral vaccine to protect against S. We recombineered the S.

To enhance survivability in the acid environment of the stomach, we created an acid-resistant strain, Ty21a-AR-Ss, by inserting Shigella glutaminase-glutamate decarboxylase systems coexpressed with S. Typhi, and survived lethal intranasal S. This paves the way for proposed good manufacturing practices manufacture and clinical trials intended to test the clinical effectiveness of Ty21a-AR-Ss in protecting against S. All rights reserved. For permissions, e-mail journals. Full Text Available Shigellosis is the major global cause of dysentery.

Shigella sonnei , which has historically been more commonly isolated in developed countries, is undergoing an unprecedented expansion across industrializing regions in Asia, Latin America, and the Middle East.

The precise reasons underpinning the epidemiological distribution of the various Shigella species and this global surge in S. First, natural passive immunization with the bacterium Plesiomonas shigelloides is hypothesized to protect populations with poor water supplies against S. Improving the quality of drinking water supplies would, therefore, result in a reduction in P.

Secondly, the ubiquitous amoeba species Acanthamoeba castellanii has been shown to phagocytize S. Finally, S. A strong selective pressure from localized antimicrobial use additionally appears to have had a dramatic impact on the evolution of the S. We hypothesize that S. Continuing improvement in the quality of global drinking water supplies alongside the rapid development of antimicrobial resistance predicts the burden and international distribution of S.

An effective vaccine against S. Full Text Available Shigella strains are important agents of bacillary dysentery, and in recent years Shigella sonnei has emerged as the leading cause of shigellosis in industrialized and rapidly developing countries.

More recently, several S. In the present study we aimed to shed light on the evolution of a recently identified Shiga toxin producing S. Here we report the first completely assembled whole genome sequence of a multidrug resistant MDR Stx-producing S. The chromosome harbors 23 prophage regions including the Stx1 converting prophage.

The genome carries all virulence determinants necessary for an enteroinvasive lifestyle, as well as the Stx1 encoding gene cluster within an earlier described inducible converting prophage. In silico SNP genotyping of the assembled genome as well as complete or draft S. Our results suggest that the acquisition of Stx phages could have occurred in different environments as independent events and that multiple horizontal transfers are responsible for the appearance of Stx phages in S.

Cytotoxicity of leukocytes from normal and Shigella -susceptible opium-treated guinea pigs against virulent Shigella sonnei. Intraepithelial lymphocytes were collected from the ileum of adult Hartley strain guinea pigs and used as effector cells in a min bactericidal assay with virulent Shigella sonnei as target cells.

Natural killer cytotoxicity NKC and antibody-dependent cellular cytotoxicity ADCC were measured and correlated with the resistance of the animals to infection by S.


Month: July 2018

Sepsis por shigella flexneri. Directory of Open Access Journals Sweden. Antibodies against Shigella flexneri adhesion molecule outer Methods: OMP was isolated from the bacterium S.


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Investigating Shigella sonnei Infections. Shigella Sonnei and Shiga Toxin. Katherine Lamba, an infectious disease epidemiologist with the California Department of Public Health, discusses Shiga Toxin producing Shigella sonnei. Directory of Open Access Journals Sweden.


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