Doc's Opinion. Apolipoprotein B ApoB is an important component of many lipoproteins that are involved in atherosclerosis and cardiovascular disease. Atherosclerosis may be described as a chronic inflammation in the arterial wall. It is caused by a complex interplay between lipoproteins, white blood cells macrophages , the immune system and the normal elements of the arterial wall.
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This test measures the amount of a certain type of cholesterol called apolipoprotein B ApoB in your blood. ApoB is the main protein found in the low-density lipoproteins LDL. LDL cholesterol is also called "bad" cholesterol because high levels of it can damage your heart and arteries.
The ApoB test helps your healthcare provider figure out your risk for cardiovascular disease. This is a disease that affects your heart and blood vessels.
You may need this test if you have a family history of heart problems. You may also need this test if you already have had heart problems such as a heart attack. Your healthcare provider may also order this test if you have a high level of fats, including cholesterol and triglycerides, in your blood. High levels of fats may raise your risk for heart problems. This test is also sometimes used to see how well treatment is working to bring down high levels of fat in your blood.
Your healthcare provider may also order a test for total cholesterol called a lipid profile. Comparing the percentages gives your provider a better idea of your heart health. Your healthcare provider may also order blood tests for other markers that help see if you are at risk for heart disease.
Test results may vary depending on your age, gender, health history, the method used for the test, and other things.
Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you. High levels of Apo B may mean that you have a higher than normal risk of developing cardiovascular disease. An Apo A test associated with "good" cholesterol may also be done with the apo B test. The ratio of the apo A results and the apo B results is sometimes used as an alternative to a total cholesterol ratio to evaluate your risk of developing cardiovascular disease.
The test is done with a blood sample. A needle is used to draw blood from a vein in your arm or hand. Having a blood test with a needle carries some risks.
These include bleeding, infection, bruising, and feeling lightheaded. When the needle pricks your arm or hand, you may feel a slight sting or pain. Afterward, the site may be sore. Usually you can't eat or drink anything except water for 9 to 12 hours before the test.
Ask your healthcare provider how long you need to fast and whether you need to stop taking any medicines before the test. Be sure your healthcare provider knows about all medicines, herbs, vitamins, and supplements you are taking. This includes medicines that don't need a prescription and any illicit drugs you may use.
Search Encyclopedia. Apolipoprotein B Does this test have other names? Why do I need this test? What other tests might I have along with this test?
What do my test results mean? How is this test done? Does this test pose any risks? What might affect my test results? Your test may be affected by: Your eating habits, especially if your diet is high in fat Taking medicines to lower cholesterol, such as statins Having certain chronic diseases such as diabetes How do I get ready for this test?
Apolipoprotein B (apoB)
Cholesterol-rich, apolipoprotein B apoB -containing lipoproteins are now widely accepted as the most important causal agents of atherosclerotic cardiovascular disease. Multiple unequivocal and orthogonal lines of evidence all converge on low-density lipoprotein and related particles as being the principal actors in the genesis of atherosclerosis. Here, we review the fundamental role of atherogenic apoB-containing lipoproteins in cardiovascular disease and several other humoral and parietal factors that are required to initiate and maintain arterial degeneration. The biology of foam cells and their interactions with high-density lipoproteins, including cholesterol efflux, are also briefly reviewed. In the ensuing decades, we learned that the key sources of cholesterol in the pathogenesis of atherosclerosis are apolipoprotein B apoB -lipoproteins from plasma.
To help evaluate your risk of developing cardiovascular disease CVD ; sometimes to help monitor treatment for high cholesterol or to help diagnose a rare inherited apolipoprotein B apo B deficiency. No special preparation is needed for an apo B test. However, since this test is often ordered at the same time as other tests that do require fasting, such as LDL-C, HDL-C and triglycerides, fasting for at least 12 hours may be required. You may be able to find your test results on your laboratory's website or patient portal. However, you are currently at Lab Tests Online.