AMELOBLASTIC ODONTOMA PDF

Ameloblastic fibroodontoma is a benign mixed odontogenic neoplasm considered in patients with asymptomatic swelling and unerupted teeth that exhibit histologic features between ameloblastic fibroma and complex odontoma. Radiographically, this lesion appears as radiolucency admixed with focal radio opaque masses of irregular shapes and sizes. This lesion is confirmed by the presence of proliferating odontogenic epithelium, ectomesenchyme, and dental hard tissue formation on pathological analysis supplementing clinical and radiographic findings. As this tumour is less commonly seen in routine clinical practice, ameloblastic fibroodontoma with detailed orofacial features and periodic approach to its diagnosis is discussed. This paper reports a case of ameloblastic fibroodontoma of the mandible in a 6-year-old male patient with an uncommon case presentation and review of the literature.

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Ameloblastic fibroodontoma is a benign mixed odontogenic neoplasm considered in patients with asymptomatic swelling and unerupted teeth that exhibit histologic features between ameloblastic fibroma and complex odontoma.

Radiographically, this lesion appears as radiolucency admixed with focal radio opaque masses of irregular shapes and sizes. This lesion is confirmed by the presence of proliferating odontogenic epithelium, ectomesenchyme, and dental hard tissue formation on pathological analysis supplementing clinical and radiographic findings.

As this tumour is less commonly seen in routine clinical practice, ameloblastic fibroodontoma with detailed orofacial features and periodic approach to its diagnosis is discussed. This paper reports a case of ameloblastic fibroodontoma of the mandible in a 6-year-old male patient with an uncommon case presentation and review of the literature. Odontogenic tumours are a diverse group of diseases ranging from simple hamartomas to neoplasms with metastatic potential [ 1 ].

This tumour is characterized by well circumscribed, asymptomatic slow expansile swelling that is usually associated with unerupted or displaced tooth [ 3 ]. Initially it was termed as ameloblastic odontoma, but due to its exceptional mixed nature of growth and incidence of two types of odontogenic tumours with diverse histological and biologic behavior, World Health Organization WHO suggested this term to be inappropriate. Later, it was aptly named as ameloblastic fibroodontoma AFO by Hooker [ 4 ].

We present a case of ameloblastic fibroodontoma AFO in a 6-year-old male patient with distinctive orofacial manifestations, radiographic findings, histopathological report, and differential diagnosis with treatment to add to the existing knowledge.

A 6-year-old male patient reported to the dental hospital with a chief complaint of swelling on the right side of face since 1 month. History revealed a slow growing and nontender swelling. Medical, personal, and family history was noncontributory. The patient was well oriented with stable vital signs. On extraoral examination, mild facial asymmetry due to swelling in the right body of mandibular region, with ill-defined margins, was evident. On palpation the swelling was asymptomatic and hard in consistency.

Skin over the swelling was normal with no evidence of secondary changes. Restricted temporomandibular joint TMJ movements and palpable lymph nodes were evident. On intraoral examination, obliteration of the buccal sulcus in molar region with buccal and lingual osseous cortical expansion was apparent Figure 1.

On palpation, the swelling was fluctuant, nontender, and fixed to the underlying bone. Orthopantomogram OPG exhibited a large radiopaque lesion surrounded by a radiolucent zone, which extended anteriorly from the lower first molar region to body of the mandible posteriorly on the right side Figure 2. Routine blood investigations were also under normal limits which ruled off evidence of any systemic disorder.

Based on clinicoradiographical findings, a provisional diagnosis of complex odontoma was made. The patient underwent enucleation of the lesion and curettage under general anesthesia. Tooth attached to the follicle around the lesion was removed.

The cavity was irrigated carefully and the debris was detached. The flap was repositioned in the same location and suturing was done with vicryl 3. On gross examination the specimen consisted of a hard tissue mass with a soft tissue attachment.

Routine histopathological examination revealed strands and islands of odontogenic epithelium with peripheral palisading nuclei resembling ameloblast-like cells and loosely arranged central cells, identical to stellate reticulum, embedded in a myxoid cell-rich stroma resembling the dental papilla.

Dentin and enamel were also present Figures 4 a and 4 b. Correlating the clinicoradiological and histopathological findings the lesion was diagnosed as ameloblastic fibroodontoma. Follow-up with this patient 2 years postoperatively exhibited good prognosis and no evidence of recurrences. Ameloblastic fibroodontoma has been conventionally classified as a benign mixed odontogenic tumour with limited cases documented in literature.

This lesion is reported in approximately 0. Children or teenagers with a mean age of 8—12 years are commonly affected with no obvious gender or anatomic site predilection.

This lesion is frequently seen in the posterior border of the mandible 2. Debate exists concerning the histogenesis of the ameloblastic fibroodontoma as a mixed odontogenic neoplasm. Previously, concept stated this lesion to be continuum of differentiation from ameloblastic fibroma to complex odontoma.

However, the recent literature stated that ameloblastic fibroodontoma as a discrete entity but it can be histologically indistinguishable from immature complex odontoma due to the presence of abundant dental hard tissue formation [ 6 ]. According to the revised World Health Organization WHO classification, ameloblastic fibroodontoma is now considered as a benign tumour without invasive growth [ 7 ]. Philipsen et al. Predominantly AFO appears hamartomatous while few others appear to have true neoplastic nature [ 10 ].

Patients present with swelling, unerupted tooth, rapid destruction, and cortical plate expansion. This case also presented with marked intraoral and extraoral swelling resulting in the obliteration of molar buccal sulcus and cortical plate expansion. World Health Organization WHO also described this well encapsulated tumour to be a benign odontogenic neoplasm admixed in primitive ectomesenchymal tissue exhibiting varying degrees of inductive changes and dental hard tissue formation [ 11 , 12 ].

Radiographically, this tumour varies from a unilocular or multilocular mixed radio-lucent radiopaque lesion with irregular size and shape to complete radio opacity as in the current case consistent with odontoma formation [ 13 , 14 ].

Histopathological examination reveals the presence of island and strands of odontogenic epithelium with peripheral columnar cells with palisading nuclei resembling ameloblast and central stellate reticulum-like cells were seen which resembled ameloblastic follicle. The mesenchymal component was fibrous and interspersed with large plump fibroblast resembling dental papilla. The dentin may vary structurally from dentinoid to tubular dentin.

Our case histopathological picture was consistent with the above findings [ 15 ]. Differential diagnosis of ameloblastic fibroodontoma includes odontoma, ameloblastoma, ameloblastic fibroma, odontoameloblastoma, calcifying epithelial odontogenic tumour, calcifying epithelial odontogenic cyst, and adenomatoid odontogenic tumour. These clinical conditions can be clearly differentiated from ameloblastic fibroodontoma based on radiographs due to the presence of dental hard tissue enamel and dentin , clinical findings, and prognosis that also supplemented our case diagnosis [ 16 ].

Ameloblastic fibroodontoma AFO includes a conservative surgical enucleation with the removal of associated tooth to prevent any further recurrences in future as performed in the above case. However, in few cases, the unerupted tooth left behind has shown good prognosis. A case of ameloblastic fibroodontoma is rare and unacquainted to a clinician due to underreported number of cases in literature. This article presents an exceptional case report of ameloblastic fibroodontoma AFO with emphasis on diagnostic criteria thus emphasizing to all the readers its importance.

Treatment of this lesion involves a complete surgical enucleation with removal of associated tooth. Additional cases need to be conveyed into certification so as to have a strong understanding concerning various aspects of this disease. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

We will be providing unlimited waivers of publication charges for accepted articles related to COVID Sign up here as a reviewer to help fast-track new submissions. Journal overview. Anshad Mohamed Abdulla, 1 G. Sivadas , 2 L. Surej Kumar, 3 C. Academic Editor: Benedetto Bruno. Received 31 May Accepted 16 Jul Published 13 Aug Abstract Ameloblastic fibroodontoma is a benign mixed odontogenic neoplasm considered in patients with asymptomatic swelling and unerupted teeth that exhibit histologic features between ameloblastic fibroma and complex odontoma.

Introduction Odontogenic tumours are a diverse group of diseases ranging from simple hamartomas to neoplasms with metastatic potential [ 1 ]. Case Presentation A 6-year-old male patient reported to the dental hospital with a chief complaint of swelling on the right side of face since 1 month. Figure 1. Intraoral examination reveals the obliteration of buccal sulcus adjacent to molar teeth with buccal and lingual cortical expansion.

Figure 2. Orthopantomogram reveals radiopaque lesion surrounded by a radiolucent zone extending anteriorly from the lower first molar region to body of the mandible posteriorly on the right side. Figure 3. Surgical enucleation of the lesion under general anesthesia. Figure 4. Histopathological specimen a reveals the presence of the lesional tissue in toto along with the attached tooth specimen.

Focal areas of enamel and dentin are also present. References A. Cavalcante, A. Anbinder, N. Costa, J. Lima, and Y. Buchner, P. Merrell, and W. Hegde and S. Singh Nanda and M. Guerrisi, M. Piloni, and A. View at: Google Scholar A. Oghli, I. Scuto, C. Ziegler, C.

Flechtenmacher, and C. E34—37, View at: Google Scholar P.

JAI JAI SURNAYAK PDF

Ameloblastic Odontoma

An year-old girl presented to our department to have a second opinion regarding a lesion involving her left mandible. She had previously undergone several radiographic exams including panoramic, helical, and cone-beam computed tomography. Our presumptive diagnosis was complex odontoma. Excisional biopsy was performed, and microscopic features showed strands and islands of odontogenic epithelium showing peripheral palisading and loosely arranged central cells, identical to stellate reticulum, embedded in a myxoid cell-rich stroma resembling the dental papilla. Dentin and enamel were also presented. The diagnosis was ameloblastic fibro-odontoma, which is a rare mixed odontogenic tumor, derived from epithelial and ectomesenchymal elements that form the dental tissues.

CYANOLOXIA BRISSONII PDF

Ameloblastic fibroodontoma or complex odontoma: Two faces of the same coin

It has been reported in the literature under a variety of names including odontoblastoma, 1 adamantoodontoma, 2 calcified mixed odontogenic tumor, 3 and soft and calcified odontoma. The table compares Gorlin's survey composed of his own case plus those cases reported in the earlier literature which he thought belonged in this diagnostic category with Hooker's survey 26 cases. Ameloblastic Odontoma : Report of Two Cases. Am J Dis Child.

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