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Epidemiological aspects of diabetes mellitus and its relationship with enviromental pollutants. Cartagena, Colombia. Universidad de Cartagena. Fax: E-mail: joliverov unicartagena. Biochemical processes involving insulin and its receptor are responsible for regulating carbohydrate and fat metabolism. Disruption of these signaling pathways could lead to obesity, insulin resistance and diabetes, among other health problems. Diabetes has a global impact and its high prevalence has been associated with genetic and environmental factors.

Recently, there has been a strong interest in establishing the relationship between type II diabetes and exposure to environmental contaminants, particularly persistent organic pollutants POPs. This association has is based on epidemiological evidence and results from in vitro and in vivo experiments. In this review, the authors present some of the epidemiological aspects of diabetes, the biochemical pathways involved in insulin action, and how these environmental toxicants have impacted on population, through diverse mechanisms, to produce this disease.

While several authors consider that the etiology of diabetes has a very important component derived from exposure to environmental pollutants, it is clear that there is still a substantial amount of work to develop in order to identify cause-effect relationships and the mechanisms involved. Key words: Organic pollutants; intracellular signaling; insulin; insulin receptor. La diabetes, es una enfermedad caracterizada por hiperglucemia, dislipidemia y resistencia a la insulina Progresa a complicaciones macrovasculares y microvasculares, con deterioro de la calidad y esperanza de vida La prevalencia en los EE.

UU es 8. De manera similar, el mercado global del tratamiento de la DMT2 fue de En este grupo se destacan las dioxinas, los furanos, los bifenilos policlorados PCB y algunos pesticidas, los cuales por sus efectos adversos fueron prohibidos en 3, 78, Existe evidencia de niveles altos de dioxinas en suero de trabajadores con diabetes 12 , y personas que viven en lugares residenciales junto a residuos de COPs Los policlorobifenilos PCB o bifenilos policlorados.

Estos datos fueron registradas igualmente por Turyk y Patel 76 , quienes reportaron datos similares. Pesticidas organoclorados. Pesticidas organofosforados. Bisfenol A BPA. Un resumen de los mismos aparece expuesto en la tabla 2. McCarthy MI. Progress in defining the molecular basis of type 2 diabetes mellitus through susceptibility-gene identification. Human molecular genetics. Obesity, inactivity, and the prevalence of diabetes and diabetes-related cardiovascular comorbidities in the U.

Diabetes Care. Relationship of polychlorinated biphenyls with type 2 diabetes and hypertension. J Environ Monit. DeFronzo RA. Pathogenesis of type 2 diabetes mellitus. Med Clin North Am. Global burden of diabetes, prevalence, numerical estimates, and projections. Diabetes Care ; 21 9 Bloomgarden ZT.

Cardiovascular disease incidence and mortality in older men with diabetes and in men with coronary heart disease. The rising global burden of diabetes and its complications: estimates and projections to theyear DiabeticMed ; 14 Suppl 5 : S Genes and type 2 diabetes mellitus. Arch Med Res. Hu FB. Globalization of diabetes: the role of diet, lifestyle, and genes. Association between polymorphism in uncoupling proteins and type 2 diabetes in a northwestern Colombian population.

Environmental contaminants as etiologic factors for diabetes. Environ Health Perspect. Prevention of type 2 diabetes: insulin resistance and beta-cell function. Environmental triggers and determinants of type 1 diabetes. Diabetes ; 54 Suppl 2:S Molecular basis of insulin action. Drug News Perspect. Hansen T. Type 2 diabetes mellitus-- a multifactorial disease.

Banting Memorial Lecture: reply from Matthews and Matthews. Type2 diabetes as an 'infectious'disease: is this the Black Death of the 21st century? Diabet Med. Global prevalence of diabetes: estimates for the year and projectionsfor Diabetes Care. Bisphenol A exposure during pregnancy disrupts glucose homeostasis in mothers and adult male offspring.

Prevalence of glucose intolerance in Asian Indians. Urban-rural difference and significance of upper body adiposity. Shah B. AK, Joshi P. New Delhi, Can inactivators of plasminogen activator inhibitor alleviate the burden of obesity and diabetes? Int J Mol Med. Prevalence of diabetes and impaired fasting glucose in adults- United States, Horton, R. Diabetes - a global threat. Lancet ; Economic costs of diabetes in the US in American Diabetes Association. Economic costs of diabetes in the U.

Diabetes Care ; 36 4 J Clin Invest Arterioscl. Kawate R. Climate and life span: regional distribution of diabetes mellitus author's transl. Nihon Ronen Igakkai Zasshi ; 17 2 The incidence of diabetes mellitus in urban and rural population in Korea. Diabetes Mellitus in Asia. Ecological aspects of Epidemiology, Complications and treatment.

Amsterdam, The Netherlands: Excerpta Medica. Prevalence of diabetes and impaired glucose tolerance in Nigerians, Jamaicans and US blacks. Ethn Dis ; 9 2 Genetic factors in type 2 diabetes: the end of the beginning?

Morbidity and mortality in workers occupationally exposed to pesticides. Arch Environ Contam Toxicol. Morphological changes in livers of rats fed polychlorinated biphenyls: light microscopy and ultrastructure.

Arch Environ Health. Ultrastructure of beta-cells of the endocrine pancreas in rats receiving polychlorinated biphenyls. Environ Physiol Biochem.

Polybrominated biphenyls, polychlorinated biphenyls, body weight, and incidence of adult-onset diabetes mellitus. Exposure to persistent organochlorine pollutants and type 2 diabetes mellitus. Hum Exp Toxicol. Physical activity, obesity, and the incidence of type 2 diabetes in a high-risk population.

Am J Epidemiol. The structure of 2Zn pig insulin crystals at 1. Insulin analog with additional disulfide bond has increased stability and preserved activity.


Triada epidemiologica




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