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Epidemiological aspects of diabetes mellitus and its relationship with enviromental pollutants. Cartagena, Colombia. Universidad de Cartagena. Fax: E-mail: joliverov unicartagena. Biochemical processes involving insulin and its receptor are responsible for regulating carbohydrate and fat metabolism. Disruption of these signaling pathways could lead to obesity, insulin resistance and diabetes, among other health problems. Diabetes has a global impact and its high prevalence has been associated with genetic and environmental factors.
Recently, there has been a strong interest in establishing the relationship between type II diabetes and exposure to environmental contaminants, particularly persistent organic pollutants POPs. This association has is based on epidemiological evidence and results from in vitro and in vivo experiments. In this review, the authors present some of the epidemiological aspects of diabetes, the biochemical pathways involved in insulin action, and how these environmental toxicants have impacted on population, through diverse mechanisms, to produce this disease.
While several authors consider that the etiology of diabetes has a very important component derived from exposure to environmental pollutants, it is clear that there is still a substantial amount of work to develop in order to identify cause-effect relationships and the mechanisms involved. Key words: Organic pollutants; intracellular signaling; insulin; insulin receptor. La diabetes, es una enfermedad caracterizada por hiperglucemia, dislipidemia y resistencia a la insulina Progresa a complicaciones macrovasculares y microvasculares, con deterioro de la calidad y esperanza de vida La prevalencia en los EE.
UU es 8. De manera similar, el mercado global del tratamiento de la DMT2 fue de En este grupo se destacan las dioxinas, los furanos, los bifenilos policlorados PCB y algunos pesticidas, los cuales por sus efectos adversos fueron prohibidos en 3, 78, Existe evidencia de niveles altos de dioxinas en suero de trabajadores con diabetes 12 , y personas que viven en lugares residenciales junto a residuos de COPs Los policlorobifenilos PCB o bifenilos policlorados.
Estos datos fueron registradas igualmente por Turyk y Patel 76 , quienes reportaron datos similares. Pesticidas organoclorados. Pesticidas organofosforados. Bisfenol A BPA. Un resumen de los mismos aparece expuesto en la tabla 2. McCarthy MI. Progress in defining the molecular basis of type 2 diabetes mellitus through susceptibility-gene identification. Human molecular genetics. Obesity, inactivity, and the prevalence of diabetes and diabetes-related cardiovascular comorbidities in the U.
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Am J Epidemiol. The structure of 2Zn pig insulin crystals at 1. Insulin analog with additional disulfide bond has increased stability and preserved activity.