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Trazodone: pharmacology and drug interactions. OBJECTIVE: To review the pharmacokinetic and pharmacodynamic properties of trazodone in order to better understand the potential of adverse events related to drug interactions. Additional references were obtained from pharmacology textbooks. The risk of adverse events due to drug interactions is acceptable and manageable, rendering trazodone a useful tool in the treatment of psychiatric and related disorders. Key-words: Trazodone, pharmacology, drug interaction, adverse drug reaction, cytochrome P

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Trazodone: pharmacology and drug interactions. OBJECTIVE: To review the pharmacokinetic and pharmacodynamic properties of trazodone in order to better understand the potential of adverse events related to drug interactions. Additional references were obtained from pharmacology textbooks. The risk of adverse events due to drug interactions is acceptable and manageable, rendering trazodone a useful tool in the treatment of psychiatric and related disorders. Key-words: Trazodone, pharmacology, drug interaction, adverse drug reaction, cytochrome P Rotzinger et al.

Marcoli et al. Enquanto a mianserina mostra uma afinidade equivalente por receptor alfa 1 e alfa 2, a trazodona demonstra ser cinco vezes mais ativa sobre alfa 1 Brogden et al.

Small et al. Quadro 1. Em , Greenblatt et al. Quadro 2. Beck et al. Segundo Thompson et al. Clin Infec Dis , J Clin Psychiatry , McGrawn Hill, New York, pp. Ann Int Med , Int Clin Psychopharmacol , Drugs , J Clin Psychopharmacol , Psiquiatria para estudantes de medicina.

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American Psychiatric Publishing, Washington, pp. CMAJ , Pharmacol Biochem Behavior , Aust N Z J Psychiatry , Br J Hosp Med , Chem Biol Interact , Gen Hosp Psychiatry , Curr Med Res Opinion , A case report. Urol Int , J Neuropsychiatry Clin Neurosci , N Engl J Med , J Clin Psychopharmacol 9: , Adv Psych Treat 8: , J Pharmacol Exp Ther , Psychopharmacology , Am Coll Obst Gyn , J Psychopharmacol , J Child Adol Psychopharmacol , Emerg Med Clin N Am , Journal of Clinical psychopharmacology , Circulation , Cell Mol Neurobiol , Drug Metabol Disposition , Ann Pharmacother , Aten Primaria , J Emerg Med , Life Sci 8: , Arch Intern Med , Eur J Pharmacol , J Am Geriatr Soc , Am Heart J , Postgrad Med , Ther Drug Monit , All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.

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