Trazodone: pharmacology and drug interactions. OBJECTIVE: To review the pharmacokinetic and pharmacodynamic properties of trazodone in order to better understand the potential of adverse events related to drug interactions. Additional references were obtained from pharmacology textbooks. The risk of adverse events due to drug interactions is acceptable and manageable, rendering trazodone a useful tool in the treatment of psychiatric and related disorders. Key-words: Trazodone, pharmacology, drug interaction, adverse drug reaction, cytochrome P
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Trazodone: pharmacology and drug interactions. OBJECTIVE: To review the pharmacokinetic and pharmacodynamic properties of trazodone in order to better understand the potential of adverse events related to drug interactions. Additional references were obtained from pharmacology textbooks. The risk of adverse events due to drug interactions is acceptable and manageable, rendering trazodone a useful tool in the treatment of psychiatric and related disorders. Key-words: Trazodone, pharmacology, drug interaction, adverse drug reaction, cytochrome P Rotzinger et al.
Marcoli et al. Enquanto a mianserina mostra uma afinidade equivalente por receptor alfa 1 e alfa 2, a trazodona demonstra ser cinco vezes mais ativa sobre alfa 1 Brogden et al.
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