EPANUTIN INJECTION PDF

Ensure ECG, blood pressure and respiratory function are monitored throughout the duration of the infusion. If phenytoin is already present but the patient is still not controlled, a 'top-up' loading dose may be useful. Table 2 gives the approximate increase in concentration following doses of —mg. The first dose should be given 12—24 hours after the loading dose. Oral or nasogastric administration should be used, whenever possible. Only use intravenous administration when these options are not feasible and where cardiac monitoring is available.

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Do not dilute solution in IV fluids. Neurosurgical procedures: see full labeling. History of prior acute hepatotoxicity due to phenytoin. Heart block and sinus bradycardia. Adams-Stokes syndrome. Concomitant delavirdine. Increased cardiovascular risk associated with rapid infusion; monitor during and after therapy; rate reduction or discontinuation may be needed. Severe myocardial insufficiency.

Change dose gradually. Maintain proper dental hygiene. Oral contraception. Pregnancy see full labeling. Nursing mothers. See Contraindications. Potentiated by acute alcohol ingestion, amiodarone, benzodiazepines eg, chlordiazepoxide, diazepam , chloramphenicol, dicumarol, disulfiram, estrogens, fluoxetine, halothane, H 2 blockers eg, cimetidine , isoniazid, methylphenidate, phenothiazines, phenylbutazone, salicylates, succinamides eg, ethosuximide , sulfonamides, tolbutamide, trazodone, others.

Antagonized by chronic alcohol ingestion, carbamazepine, reserpine, others. Antagonizes tricyclic antidepressants, oral anticoagulants, oral contraceptives, estrogens, corticosteroids, doxycycline, digitoxin, furosemide, theophylline, rifampin, quinidine, vitamins D and K, others. Variable effects with phenobarbital, valproic acid, divalproex, others. Absorption decreased by calcium. Nystagmus, drowsiness, dizziness, insomnia, dyskinesias, ataxia, GI disturbances, gingival hyperplasia, osteomalacia, blood dyscrasias, atrial and ventricular conduction depression, slurred speech, lymphadenopathy, hepatic disease, rash, hyperglycemia, SLE, hypertrichosis, immunoglobulin abnormalities; DRESS, multiorgan hypersensitivity may be fatal , local toxicity eg, purple glove syndrome.

Indications for Phenytoin Injection: Status epilepticus tonic-clonic. Seizure prophylaxis and treatment in neurosurgery. Contraindications: History of prior acute hepatotoxicity due to phenytoin. Pharmacologic Class: Hydantoin. Interactions: See Contraindications. Adverse Reactions: Nystagmus, drowsiness, dizziness, insomnia, dyskinesias, ataxia, GI disturbances, gingival hyperplasia, osteomalacia, blood dyscrasias, atrial and ventricular conduction depression, slurred speech, lymphadenopathy, hepatic disease, rash, hyperglycemia, SLE, hypertrichosis, immunoglobulin abnormalities; DRESS, multiorgan hypersensitivity may be fatal , local toxicity eg, purple glove syndrome.

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PHENYTOIN SODIUM PFIZER READY-MIXED PARENTERAL 250MG/5ML SOLUTION FOR INJECTION OR INFUSION

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Epanutin injection (phenytoin)

Epanutin injection contains the active ingredient phenytoin, which is a type of medicine called an anticonvulsant. Phenytoin works by stabilising electrical activity in the brain. The brain and nerves are made up of many nerve cells that communicate with each other through electrical signals. These signals must be carefully regulated for the brain and nerves to function properly. When abnormally rapid and repetitive electrical signals are released in the brain, the brain becomes over-stimulated and normal function is disturbed.

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EPANUTIN READY-MIXED PARENTERAL 250MG/5ML SOLUTION FOR INJECTION OR INFUSION

Do not dilute solution in IV fluids. Neurosurgical procedures: see full labeling. History of prior acute hepatotoxicity due to phenytoin. Heart block and sinus bradycardia. Adams-Stokes syndrome.

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