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The scientific literature reports that about , cases of spinal-cord injuries SCI occur yearly in the world. Recent publications show neurological benefit in selected quadriplegics undergoing intra-lesion transplantation of autologous cultured bone-marrow mesenchymal stem cells.

Objectives: This case-study reports level—III objective evidence and partial neurological clinical recovery in a year old-male with chronic complete quadriplegia that underwent somatic nuclear cell transfer SCNT and embryonic cell therapy for traumatic spinal-cord injury SCI sustained 6-years previously. Material and methods : Cell-transplantation was by neuro-surgical implantation into the damaged cervical cord 6-years after SCI that rendered the patient a complete quadriplegic confirmed on neurological examination and magnetic resonance imaging MRI.

Results: Neurological improvement was asymmetrically improved in the shoulder girdle, upper extremity bilaterally and trunk without dramatic change in leg-function at months. Conclusion: Compared to baseline findings, measured neurological improvement was documented in the shoulder-girdle and upper-extremities, months after intra-lesion autologous SCNT cell transplantation in a chronic-quadriplegic. Locomotor training after human spinal-cord injury: a series of case-studies.

Phys Ther Relationship between ASIA examination and functional outcomes in the neuro-recovery network locomotor training program. Arch Phys Med Rehabil Burns L. Theor Med Bioeth Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature Cloned rabbits produced by nuclear transfer from adult somatic cells. Nat Bio-technol Transplantation of autologous bone marrow mesenchymal stem cells in the treatment of complete and chronic cervical spinal cord injury.

Brain Res [Epub ahead of print]. Dietz V and Curt A. Neurological aspects of spinal-cord repair: promises and challenges. Lancet Neurol 5: Guidelines for the conduct of clinical-trials for spinal-cord injury as developed by the ICCP panel: spontaneous recovery after spinal-cord injury and statistical power needed for therapeutic clinical-trials.

Spinal Cord Development of human cloned blastocysts following somatic cell nuclear transfer with adult fibroblasts. Stem Cells J Assist Reprod Genet [Epub ahead of print]. New strategies for repairing the injured spinal-cord: the role of stem cells. Neurol Res Goldman S. Nat Biotechnol Hagg T, Oudega M. Degenerative and spontaneous regenerative processes after spinal-cord injury. J Neurotrauma Patient-specific embryonic stem cells derived from human SCNT blastocysts.

Science A clinical trial report of autologous bone marrow-derived mesenchymal stem cell transplantation in patients with spinal-cord injury. Experimental and Therapeutic Medicine 6: Human embryonic stem cell-derived oligodendrocyte progenitor-cell transplants remyelinate and restore locomotion after spinal-cord injury. The Journal of Neuroscience Production of cloned mice by nuclear transfer of cumulus cells. Avicenna J Med Biotechnol Human neural stem cells promote cortico-spinal axons regeneration and synapse-reformation in injured spinal-cord of rats.

Chinese Med J Engl Development of a model of sacrocaudal spinal cord injury in cloned Yucatan minipigs for cellular transplantation research.

Cell Reprogram Medical Research Council. Aids to the examination of the peripheral nervous system. Memorandum No Moodley K. Medical Ethics, Law and Human Rights. A South-African Perspective. Van Schaik Publishers, Pretoria. Neuroprotective and growth-promoting effects of bone-marrow stromal cells after cervical spinal-cord injury in adult-rats. Cytotherapy Transplantation of neural stem cells into the spinal-cord after injury.

Semin Cell Dev Biol Cloned mice from fetal fibroblast cells arrested at metaphase by a serial nuclear transfer. Biol Reprod Ota M, Ito. Induction of neurogenin-1 expression by sonic hedgehog: Its role in development of trigeminal sensory neurons.

Dev Dyn Induction of human neuronal cells by defined transcription factors. The effect of mesenchymal stem cell transplantation on the recovery of bladder and hind-limb function after spinal-cord contusion in rats. BMC Neurosci Cell-based transplantation strategies to promote plasticity following spinal cord injury. Exp Neurol Spinal-cord injury models in non-human primates: are lesions created by sharp instruments relevant to human injuries?

Med Hypotheses Extent of spontaneous motor recovery after traumatic cervical sensorimotor complete spinal cord injury. Human embryonic stem cells derived by somatic cell nuclear transfer. Cell Direct conversion of fibroblasts to functional neurons by defined factors.

Wakayama T, Yanagimachi R. Cloning of male mice from adult tail-tip cells. Nat Genet Viable offspring derived from fetal and adult mammalian cells. Stem cells for spinal-cord repair.

Cell Stem Cell 3: Kidson SH. Stem cell transplantation-a collegial conservation. SAMJ Moore KL. Willadsen SM. Nuclear transplantation in sheep embryos PDF English.

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